What is Clenbuterol? What Does It Do? How Is It Used?

Clenbuterol (Clen) is a selective beta-2 agonist/antagonist and a bronchodilator. What this means is that it stimulates beta-2 receptors. Of great importance is that clenbuterol is a selective beta-2 agonist (since it works selectively on the beta-2-adrenergic receptors), right? The thing is, Clenbuterol is selective... like hitting a nail (the tactic being its beta-2 receptor) with a small hammer (the hammer being Clen)... thus, it leads to beta-2 receptors selectively. I'm sorry if this seems repetitive, but it's crucial to understand this before moving forward. Since Clenbuterol has little beta-1 stimulation capacity, it has the ability to reduce certain types of airway obstruction without much in the way of cardiovascular effect (more on this later), and therefore it is used as an asthma medication.

What exactly does a stimulant like Clenbuterol do when it stimulates beta receptors?

Well, it serves to increase your body temperature slightly by increasing heat production in the mitochondria, boosting basal metabolic rate, and decreasing appetite. This partly explains how beta-2 agonists directly stimulate fat cells and increase lipolysis (fat loss). And also, since it's a beta-2 agent, Clenbuterol can decrease insulin sensitivity, unfortunately.

Clenbuterol is a very effective partitioning agent, and this is what is most commonly used in athletic circles. It will increase your free fat mass (FFM) to fat mass ratio, decrease fat, and possibly increase your mission.

Based on its body clearance rate, and how much it takes to be effective for athletes, my recommendations are the same for men and women. You'll need to take 20mcgs in the morning, and then repeat the same dose throughout the day, and then again on that day (if you find they can tolerate the effects). So start with 20mcgs and repeat the dose twice the same day if you can tolerate (side effects will determine this hand tremor, sweating, etc. sides and classic stimulants). Then you can start gradually increasing the dose. Personally, I would like to work my way up to 200mcg/day. 60-120mcg/day is a middle dose. And keep your blood pressure at (or below) 140/90, while on Clenbuterol, just to be safe. If you go over that, lower the dose. You also want to know your body temperature, in the morning, for the week before starting to take Clenbuterol, and then monitor (again, as soon as you wake up) throughout your Clenbuterol regimen. When it returns to the level before starting to take Clenbuterol, you have to start taking your Benadryl or ketotifen, as the decrease in body temperature to original levels indicates that the thermogenic effect is starting to decline.

Clenbuterol can also cause downregulation of testicular androgen receptors and central nervous system, cardiac, and pulmonary beta-adrenergic agonists (6.) Possibly making steroids less effective (if there is a decrease in androgen receptor expression elsewhere, then it is very likely) while on Clenbuterol, but Clenbuterol definitely effectiveness over time and you take this medication. To counteract this, you can take some ketotifen every 3 or 4 weeks that you're on Clenbuterol. This is an anti-histamine prescription, so it will make you drowsy (take before bedtime). Basically, the way this works is by reducing the activity of beta-2 receptors, and restoring receptor function.

Finally, this brings up the issue of cramps while on Clenbuterol. Most of us are athletes who use clenbuterol during the season and offseason, and one of my friends went so far as to say that it gives him more "wind" (cardiovascular endurance). Drink plenty of water every day and you should be fine. If you're really interested, you can take some extra minerals and taurine, as Clenbuterol depletes taurine more than, if not all, beta agonists. It's nothing more than renegade from my usual vitamins and minerals.

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