PRILIMED 30 (Dapoxetine HCl): Fast-Acting Treatment for Premature Ejaculation

Active Substance: Dapoxetine HCl ($30 \text{ mg/tab}$)

Manufacturer: Deus Medical

Pack: 1 Box of 2x 25 Tablets ($30 \text{ mg}$ per Tablet)

Form: Oral

What Is Dapoxetine HCl (PRILIMED 30)?

PRILIMED 30 contains Dapoxetine Hydrochloride, a medication specifically developed and used for the treatment of premature ejaculation (²$\text{PE}$) in men.³

Dapoxetine belongs to the class of drugs known as Selective Serotonin Reuptake Inhibitors (⁴$\text{SSRIs}$).⁵ Its unique property is its short-acting nature, which allows it to be taken on demand, shortly before sexual activity, unlike other ⁶$\text{SSRIs}$ that require chronic daily dosing for mood disorders.⁷

Core Functions and Mechanism

• Ejaculation Control: Dapoxetine works by inhibiting the reuptake of serotonin in the synaptic cleft.⁸ Increased serotonin levels in the central nervous system (⁹$\text{CNS}$) help to increase the time required to reach ejaculation, thereby improving control and satisfaction.¹⁰

• Short-Acting Profile: Dapoxetine is absorbed and eliminated rapidly.¹¹ Its rapid onset (¹²$\sim 1 \text{ hour}$) and quick clearance means it does not accumulate in the body, minimizing the long-term side effects typically associated with chronic ¹³$\text{SSRI}$ use.¹⁴

 Usage and Dosage Protocols

Dapoxetine is used on an as-needed basis only, immediately prior to sexual activity.¹⁵

• Recommended Starting Dose: The recommended initial starting dose is ¹⁶$30 \text{ mg}$.¹⁷

• Timing: The dose should be taken as needed, approximately 1 to 3 hours before sexual activity.¹⁸

• Maximum Dose: If the response to ¹⁹$30 \text{ mg}$ is insufficient and the user has not experienced moderate or severe adverse reactions, the dose may be increased to a maximum recommended dose of ²⁰$60 \text{ mg}$.²¹

• Frequency: Dapoxetine should not be used chronically on a daily basis and should not be taken more frequently than once every 24 hours.²²

• Caution: The incidence and severity of adverse events are greater at the ²³$60 \text{ mg}$ dose.²⁴

 Side Effects and Warnings

As an ²⁵$\text{SSRI}$, Dapoxetine can cause side effects related to the central nervous system (²⁶$\text{CNS}$).²⁷

• Common Side Effects: Dizziness, headache, nausea, and diarrhea are common, particularly at higher doses.²⁸

• Syncope Risk: There is a risk of syncope (fainting), often preceded by prodromal symptoms (like dizziness or palpitations).²⁹ Users should be aware of these symptoms, especially when increasing the dose.

• Drug Interactions: Dapoxetine may interact with other medications, particularly other ³⁰$\text{SSRIs}$, ³¹$\text{MAO}$ inhibitors, and certain antifungal drugs.³²

 Frequently Asked Questions (FAQs)

1. Why is Dapoxetine considered unique among $\text{SSRIs}$?

Dapoxetine is unique because it is specifically designed to be short-acting.³³ Its rapid absorption and elimination mean it is suitable for on-demand use shortly before sexual activity.³⁴ Other $\text{SSRIs}$ (used for depression) have long half-lives and must be taken daily for weeks to become effective, making them unsuitable for episodic $\text{PE}$ treatment.

2. Can Dapoxetine be stacked with a $\text{PDE}5$ Inhibitor (like Tadalafil)?

Yes, it is common. Dapoxetine treats the timing issue ($\text{PE}$), while a $\text{PDE}5$ inhibitor (like Tadalafil or Sildenafil) treats the erection quality issue ($\text{ED}$). Because the two drugs target different mechanisms, they are often used together to address both aspects of male sexual dysfunction.

3. Should I take Dapoxetine every day for better results?

No. Dapoxetine is designed to be taken as needed.³⁵ Chronic, daily use is not recommended and increases the risk of side effects associated with continuous $\text{SSRI}$ activity. It should be taken $1 \text{ to } 3 \text{ hours}$ before the anticipated sexual activity.

4. What are the signs that I should not increase my dose from $30 \text{ mg}$ to $60 \text{ mg}$?

You should not increase the dose if you have experienced any moderate or severe adverse reactions or any prodromal symptoms suggestive of syncope (e.g., sudden sweating, lightheadedness, dizziness, or palpitations) while taking the $30 \text{ mg}$ dose. Given the higher risk profile of the $60 \text{ mg}$ dose, caution is strongly advised.