Ipamorelin: The Selective Growth Hormone Secretagogue (GH-Secretagogue)¹

Active Component: Growth Hormone-Releasing Peptide (Ipamorelin)

Manufacturer: Deus Medical

Pack: 1 Vial x 2 mg

Form: Injectable

What Is Ipamorelin?

Ipamorelin is a powerful and highly regarded peptide classified as a Growth Hormone Secretagogue (GHS) and a Ghrelin Receptor Agonist.² It stimulates the pituitary gland to release the body's natural Growth Hormone (GH).

Ipamorelin is considered the first selective GH Secretagogue and arguably the best, due to its ability to generate a potent GH pulse while minimizing the release of unwanted hormones that cause common side effects.³

Core Functions and Superiority

• Selective GH Release: Ipamorelin is unique because, unlike other GH-Secretagogues (like GHRP-6), this pentapeptide does not release significant volumes of Cortisol, Acetylcholine, Prolactin, or Aldosterone.⁴ This cleaner release means fewer side effects and a higher therapeutic ratio.

• Potent Anabolic Action: The strong, clean pulse of GH leads to elevated levels of the anabolic hormone IGF-1 (Insulin-like Growth Factor 1), promoting muscle growth, fat loss, and superior recovery.

• Minimal Hunger Stimulation: Ipamorelin generates a potent GH pulse comparable to GHRP-6 but with less appetite stimulation, making it easier to manage diet during both bulking and cutting cycles.

• Anti-Aging and Recovery: Elevated GH levels enhance tissue repair, improve sleep quality, and support joint health.

 Usage and Dosage Protocols

Ipamorelin has a short half-life and is most effective when injected multiple times a day or combined with a long-acting partner.

• Administration: Inject a minimum of $200 \text{ mcg}$ subcutaneously once daily, 5 out of 7 days of the week. Due to the short half-life, multiple daily injections (2–3 times) are often preferred for maximizing GH levels.

• Stacking Recommendation: It is highly recommended to use Ipamorelin in combination with a Growth Hormone-Releasing Hormone ($\text{GHRH}$) analog like CJC-1295 (with or without $\text{DAC}$).

  • Synergistic Effect: The combination provides a synergistic effect, generating up to five times the benefits of using the peptides alone, as they act on different receptors ($\text{Ghrelin-R}$ and $\text{GHRH-R}$) to maximize GH release.

 Side Effects

Due to its high selectivity, Ipamorelin has a very clean side-effect profile, with minimal impact on Prolactin and Cortisol compared to other GHRPs.⁵ Common minor side effects may include flushing, headache, and temporary irritation at the injection site.⁶

 Frequently Asked Questions (FAQs)

1. Why is Ipamorelin considered the "best" or most selective GH Secretagogue?

Ipamorelin is highly selective because it targets the GH receptor without significantly increasing the release of unwanted hormones like Cortisol, Prolactin, and Aldosterone.⁷ High levels of these hormones are often linked to side effects like aggression, water retention, and sexual dysfunction with older $\text{GHRP}$s. Ipamorelin minimizes these co-secretions.⁸

2. Is Ipamorelin used alone or is stacking necessary?

While Ipamorelin is effective alone, stacking with a GHRH analog (like CJC-1295) is strongly recommended.⁹ The Ipamorelin initiates the GH pulse, and the GHRH analog amplifies the pulse size. The synergistic action results in a significantly more potent total GH release and enhanced benefits.

3. Does Ipamorelin require Post Cycle Therapy (PCT)?

No. Ipamorelin is a peptide that stimulates the body's natural GH axis, not the $\text{HPTA}$ (Hypothalamic-Pituitary-Testicular Axis). It does not suppress the body's natural production of testosterone. Therefore, Ipamorelin cycles do not require standard $\text{PCT}$ protocols.

4. How does Ipamorelin's effect on hunger compare to GHRP-6?

Ipamorelin has a significantly milder effect on hunger compared to $\text{GHRP-6}$. $\text{GHRP-6}$ is notorious for causing intense, immediate hunger (due to increased gastric motility). Ipamorelin provides the powerful GH pulse without the drastic appetite stimulation, making it easier to control calories during a cutting or recomp cycle.¹⁰